Water → 3-Bromo-4-fluorobenzyl Alcohol

HRID 2390588Notes

Reaction equation

HRID 2390588 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH:5]=[O:6].[BH4-].[Na+].O>CO>[Br:1][C:2]1[CH:3]=[C:4]([CH2:5][OH:6])[CH:7]=[CH:8][C:9]=1[F:10]

Participants

5

Reactant 3

HCID 962WaterHCID 1736043-Bromo-4-fluorobenzaldehydeHCID 4311764Sodium borohydride

Product 1

HCID 27733513-Bromo-4-fluorobenzyl Alcohol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 5 g (24.6 mmol) 3-bromo-4-fluoro-benzaldehyde in 20 ml anhydrous methanol is mixed in portions with 1.38 g (36.58 mmol) sodium borohydride while stirring and stirred for another hour at room temperature. After adding water, an extraction is carried out using diethyl ether, and the organic phase is dried over sodium sulfate. After the solvent is removed under vacuum, the appropriate alcohol is obtained. The product is obtained in pure form and can be used for further reactions.

Workup

  1. stirringstirred for another hour at room temperature
  2. extractionan extraction
  3. dry with materialthe organic phase is dried over sodium sulfate
  4. customAfter the solvent is removed under vacuum

Sources & evidence

ORD record
ord-70ef5bd33b31446d8d16ed7b33d25c46
Source dataset
uspto-grants-2012_09
Patent number
US08273793B2

Reaction notes

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