HRID2390729

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12303314

1-Methyl-1H-indole-2-carbonyl chloride

C10H8ClNO

结构：COc1cc(-c2csc3c(NC(=O)CCN4CCC(O)CC4)cnc(N)c23)ccc1N

HCID18451406

未命名化合物

PRODUCTS

生成物

结构：COc1cc(-c2csc3c(NC(=O)CCN4CCC(O)CC4)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C

HCID18451117

未命名化合物

PROCEDURE

实验过程

The title compound was prepared using 1-methyl-1H-indole-2-carbonyl chloride, N-[4-Amino-3-(4-amino-3-methoxyphenyl)-thieno[3,2-c]pyridin-7-yl]-3-(4-hydroxy-piperidin-1-yl)propionamide, and the procedure described in General Procedure F. m/z (M+H)+599.4.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-30d634b1269a4a9fb64565bbf3761110
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273736B2
来源说明: uspto-grants-2012_09

反应 SMILES

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[C:11](Cl)=[O:12].[NH2:14][C:15]1[C:20]2[C:21]([C:24]3[CH:29]=[CH:28][C:27]([NH2:30])=[C:26]([O:31][CH3:32])[CH:25]=3)=[CH:22][S:23][C:19]=2[C:18]([NH:33][C:34](=[O:44])[CH2:35][CH2:36][N:37]2[CH2:42][CH2:41][CH:40]([OH:43])[CH2:39][CH2:38]2)=[CH:17][N:16]=1>>[NH2:14][C:15]1[C:20]2[C:21]([C:24]3[CH:29]=[CH:28][C:27]([NH:30][C:11]([C:3]4[N:2]([CH3:1])[C:10]5[C:5]([CH:4]=4)=[CH:6][CH:7]=[CH:8][CH:9]=5)=[O:12])=[C:26]([O:31][CH3:32])[CH:25]=3)=[CH:22][S:23][C:19]=2[C:18]([NH:33][C:34](=[O:44])[CH2:35][CH2:36][N:37]2[CH2:38][CH2:39][CH:40]([OH:43])[CH2:41][CH2:42]2)=[CH:17][N:16]=1