反应详情

step 2—A mixture of 22 (1.95 g) and Pd/C (10% wt. on carbon, 50 mg) in EtOAc (15 mL) and EtOH (15 mL) at RT was stirred under 1 atmosphere of H2 for 45 min. The catalyst was filtered off and the filtrate was concentrated. The crude residue was purified by SiO2 chromatography eluting with a EtOAc/hexane gradient (0 to 5% EtOAc) to afford 560 mg of 2-ethyl-6-methoxypyridine (26) as a colorless oil.

1. filtrationThe catalyst was filtered off
2. concentrationthe filtrate was concentrated
3. customThe crude residue was purified by SiO2 chromatography
4. washeluting with a EtOAc/hexane gradient (0 to 5% EtOAc)