反应详情

I-236 was prepared analogously except in step 4, 5-fluoro-2-methoxy-pyridin-3-yl boronic acid was replaced with 2,6-dimethoxy-pyridin-3-yl boronic acid. The crude material was purified by trituration in 10% methanol in ethyl acetate (10 mL). The solid was filtered and dried to give the 6-methoxy pyridone.

1. customThe crude material was purified by trituration in 10% methanol in ethyl acetate (10 mL)
2. filtrationThe solid was filtered
3. customdried