(2,6-Dimethoxypyridin-3-yl)boronic acid → 6-Methoxypyridin-2-ol

HRID 2390845Notes

Reaction equation

HRID 2390845 reaction equation
FC1C=C(B(O)O)C(OC)=NC=1.[CH3:13][O:14][C:15]1[C:20](B(O)O)=[CH:19][CH:18]=[C:17]([O:24]C)[N:16]=1>>[CH3:13][O:14][C:15]1[NH:16][C:17](=[O:24])[CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 2762707(2,6-Dimethoxypyridin-3-yl)boronic acidHCID 447176915-Fluoro-2-methoxypyridine-3-boronic acid

Product 1

HCID 126787246-Methoxypyridin-2-ol

Procedure

I-236 was prepared analogously except in step 4, 5-fluoro-2-methoxy-pyridin-3-yl boronic acid was replaced with 2,6-dimethoxy-pyridin-3-yl boronic acid. The crude material was purified by trituration in 10% methanol in ethyl acetate (10 mL). The solid was filtered and dried to give the 6-methoxy pyridone.

Workup

  1. customThe crude material was purified by trituration in 10% methanol in ethyl acetate (10 mL)
  2. filtrationThe solid was filtered
  3. customdried

Sources & evidence

ORD record
ord-94927ff9e27d4e1190ba42b157379e8b
Source dataset
uspto-grants-2012_09
Patent number
US08273773B2

Reaction notes

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