HRID2390854

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2763121

2-METHOXY-6-METHYLPYRIDINE-3-BORONIC ACID

C7H10BNO3

结构：COCc1cc(NS(C)(=O)=O)ccc1/C=C/c1cc(Br)cc(C(C)(C)C)c1OC

HCID67286866

未命名化合物

PRODUCTS

生成物

结构：COCc1cc(NS(C)(=O)=O)ccc1/C=C/c1cc(-c2ccc(C)nc2OC)cc(C(C)(C)C)c1OC

HCID67070031

未命名化合物

PROCEDURE

实验过程

step 1—Cross coupling of 315 and 6-methyl-2-methoxy-3-pyridine boronic acid (316, CASRN 1000802-754) was carried out in accord with the procedure in step 4 of example 38 except 107 was replaced with 316 which afforded N-(4-{(E)-2-[3-tert-butyl-2-methoxy-5-(2-methoxy-6-methyl-pyridin-3-yl)-phenyl]-vinyl}-3-methoxymethyl-phenyl)-methanesulfonamide (318).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bb418001bf234ec7ba8b393bc135a3f3
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273773B2
来源说明: uspto-grants-2012_09

反应 SMILES

Br[C:2]1[CH:3]=[C:4]([C:26]([CH3:29])([CH3:28])[CH3:27])[C:5]([O:24][CH3:25])=[C:6](/[CH:8]=[CH:9]/[C:10]2[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[CH:12][C:11]=2[CH2:21][O:22][CH3:23])[CH:7]=1.[CH3:30][C:31]1[N:36]=[C:35]([O:37][CH3:38])[C:34](B(O)O)=[CH:33][CH:32]=1>>[C:26]([C:4]1[C:5]([O:24][CH3:25])=[C:6](/[CH:8]=[CH:9]/[C:10]2[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[CH:12][C:11]=2[CH2:21][O:22][CH3:23])[CH:7]=[C:2]([C:34]2[C:35]([O:37][CH3:38])=[N:36][C:31]([CH3:30])=[CH:32][CH:33]=2)[CH:3]=1)([CH3:29])([CH3:27])[CH3:28]