2-Methoxy-6-methylpyridine-3-boronic acid → N-(4-{(E)-2-[3-tert-butyl-2-methoxy-5-(2-methoxy-6-methyl-pyridin-3-yl)-phenyl]-vinyl}-3-methoxymethyl-phenyl)-methanesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	2-Methoxy-6-methylpyridine-3-boronic acid	HCID 2763121	—
Reactant	N-{4-[(E)-2-(5-bromo-3-tert-butyl-2-methoxy-phenyl)-vinyl]-3-methoxymethyl-phenyl}-methanesulfonamide	HCID 67286866	—
Product	N-(4-{(E)-2-[3-tert-butyl-2-methoxy-5-(2-methoxy-6-methyl-pyridin-3-yl)-phenyl]-vinyl}-3-methoxymethyl-phenyl)-methanesulfonamide	HCID 67070031	—

Reaction Steps

step 1—Cross coupling of 315 and 6-methyl-2-methoxy-3-pyridine boronic acid (316, CASRN 1000802-754) was carried out in accord with the procedure in step 4 of example 38 except 107 was replaced with 316 which afforded N-(4-{(E)-2-[3-tert-butyl-2-methoxy-5-(2-methoxy-6-methyl-pyridin-3-yl)-phenyl]-vinyl}-3-methoxymethyl-phenyl)-methanesulfonamide (318).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273773B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-bb418001bf234ec7ba8b393bc135a3f3
Source note	uspto-grants-2012_09