Lithium hydroxide, monohydrate → HCID 67069883, compound

HRID 2390859Notes

Reaction equation

HRID 2390859 reaction equation
[C:1]([C:5]1[C:6]([O:37][CH3:38])=[C:7](/[CH:20]=[CH:21]/[C:22]2[CH:31]=[CH:30][C:29]([NH:32][S:33]([CH3:36])(=[O:35])=[O:34])=[CH:28][C:23]=2[C:24]([O:26]C)=[O:25])[CH:8]=[C:9]([C:11]2[C:12](=[O:19])[NH:13][C:14]([O:17][CH3:18])=[CH:15][CH:16]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].O[Li].O>>[C:1]([C:5]1[C:6]([O:37][CH3:38])=[C:7](/[CH:20]=[CH:21]/[C:22]2[CH:31]=[CH:30][C:29]([NH:32][S:33]([CH3:36])(=[O:34])=[O:35])=[CH:28][C:23]=2[C:24]([OH:26])=[O:25])[CH:8]=[C:9]([C:11]2[C:12](=[O:19])[NH:13][C:14]([O:17][CH3:18])=[CH:15][CH:16]=2)[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 67287587HCID 67287587, compound

Product 1

HCID 67069883HCID 67069883, compound

Procedure

The title compound was prepared by saponification of 328 with LiOH.H2O. The product was purified by SiO2 chromatography eluting with 5% MeOH/DCM to afford I-211.

Workup

  1. customThe product was purified by SiO2 chromatography
  2. washeluting with 5% MeOH/DCM
  3. customto afford I-211

Sources & evidence

ORD record
ord-8ce3827563ab4d83b3c06dbb77dcd495
Source dataset
uspto-grants-2012_09
Patent number
US08273773B2

Reaction notes

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