Trifluoroacetic acid → HCID 59156712, compound

HRID 2390883Notes

Reaction equation

HRID 2390883 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([C:26]2[C:27](=[O:47])[N:28]([CH2:33][O:34][P:35](=[O:46])([O:41]C(C)(C)C)[O:36]C(C)(C)C)[CH:29]=[C:30]([F:32])[CH:31]=2)[CH:8]=[C:9](/[CH:13]=[CH:14]/[C:15]2[CH:20]=[CH:19][C:18]([NH:21][S:22]([CH3:25])(=[O:24])=[O:23])=[CH:17][CH:16]=2)[C:10]=1[O:11][CH3:12])([CH3:4])([CH3:3])[CH3:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([C:5]1[CH:6]=[C:7]([C:26]2[C:27](=[O:47])[N:28]([CH2:33][O:34][P:35](=[O:36])([OH:41])[OH:46])[CH:29]=[C:30]([F:32])[CH:31]=2)[CH:8]=[C:9](/[CH:13]=[CH:14]/[C:15]2[CH:16]=[CH:17][C:18]([NH:21][S:22]([CH3:25])(=[O:24])=[O:23])=[CH:19][CH:20]=2)[C:10]=1[O:11][CH3:12])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67286279HCID 67286279, compound

Product 1

HCID 59156712HCID 59156712, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

step 3—To a solution of 346 and DCM (10 mL) at RT under an Ar atmosphere was added TFA (0.523 mL, 6.78 mmol). The resulting solution was stirred for 3 h. The solution was concentrated in vacuo and the residue twice taken up in benzene and re-evaporated to afford 0.346 g of I-8: MS (M+H)=581.

Workup

  1. concentrationThe solution was concentrated in vacuo
  2. customre-evaporated
  3. customto afford 0.346 g of I-8: MS (M+H)=581

Sources & evidence

ORD record
ord-03d9f51490e4404ea296879b427bd47f
Source dataset
uspto-grants-2012_09
Patent number
US08273773B2

Reaction notes

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