Thiourea → 5,6,7,8-tetrahydro-4H-Thiazolo[4,5-d]azepin-2-amine hydrobromide

HRID 239096Notes

Reaction equation

HRID 239096 reaction equation
[NH2:1][C:2]([NH2:4])=[S:3].Br.[Br:6][CH:7]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][C:8]1=O>C(O)C>[BrH:6].[S:3]1[C:7]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][C:8]=2[N:1]=[C:2]1[NH2:4]

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 226207665-Bromoazepan-4-one hydrobromide

Product 1

HCID 866860295,6,7,8-tetrahydro-4H-Thiazolo[4,5-d]azepin-2-amine hydrobromideYield 103.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

1.44 g thiourea was added to 4 g 5-bromo-azepan-4-one hydrobromide in 50 mL ethanol and stirred 3 h at 80° C. and over the weekend at RT. The precipitate was filtered and dried to yield 3.8 g of the product.

Workup

  1. filtrationThe precipitate was filtered
  2. customdried

Sources & evidence

ORD record
ord-39df6a185c8547c2b9c3bdcbe6a8d702
Source dataset
uspto-grants-2014_02
Patent number
US08642774B2

Reaction notes

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