反应详情

10% TFA in 60 ml chloroform was added to 2.3 g 2-(3-methyl-ureido)-6,7-dihydro-4H-thiazolo-[5,4-c]pyridine-5-carboxylic acid tert-butyl ester in 28 ml chloroform and stirred for 2 h at RT. The mixture was concentrated, the residue was diluted with chloroform and basified with 2.5 M aqueous potassium carbonate solution and extracted with chloroform. The organic layer was concentrated. The residue was washed with a mixture of 50% ethyl acetate and 50% hexane to yield 1.5 g of the desired product. (M+H)+: 213

1. concentrationThe mixture was concentrated
2. additionthe residue was diluted with chloroform
3. extractionextracted with chloroform
4. concentrationThe organic layer was concentrated
5. washThe residue was washed with a mixture of 50% ethyl acetate and 50% hexane