3-Chloro-2-butanone → HCID 86686485, compound

HRID 239106Notes

Reaction equation

HRID 239106 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([NH2:16])=[O:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH:18]([CH3:22])[C:19](=O)[CH3:20]>CO>[CH2:1]([N:8]1[CH2:9][CH2:10][CH:11]([C:14]2[O:15][C:18]([CH3:22])=[C:19]([CH3:20])[N:16]=2)[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 200263-Chloro-2-butanoneHCID 7831561-Benzylpiperidine-4-carboxamide

Product 1

HCID 86686485HCID 86686485, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

7 g 1-benzyl-piperidine-4-carboxylic acid amide and 13 mL 3-chlorobutan-2-on were stirred 6 h at 180° C. under microwave conditions. The mixture was diluted in methanol and n-methylpyridinone and purified by HPLC to give 1.48 g of the desired product.

Workup

  1. customn-methylpyridinone and purified by HPLC

Sources & evidence

ORD record
ord-b70e4ae06675439e9ff5076016b0480d
Source dataset
uspto-grants-2014_02
Patent number
US08642774B2

Reaction notes

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