反应详情

1 g sodium hydride (60% oil dispersion) was added to 7 g 3-(1-benzyl-piperidin-4-yl)-3,4-dihydro-1H-quinazolin-2-one at 0° C. under nitrogen. The reaction was stirred at RT for 1 h and 1.5 mL methyliodide was added. The reaction was stirred 1 h at RT and poured into 600 mL water. The water layer was extracted with ethyl acetate. The organic layer was dried and evaporated to give 7.3 g of the desired product.

1. stirringThe reaction was stirred 1 h at RT
2. extractionThe water layer was extracted with ethyl acetate
3. customThe organic layer was dried
4. customevaporated