Sodium Hydroxide → 1,4-Dimethyl-1H-pyrazole-3-carboxylic acid

HRID 2391133Notes

Reaction equation

HRID 2391133 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[C:4]([C:8]([O:10]CC)=[O:9])=[N:3]1.[OH-].[Na+]>C(O)C>[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[C:4]([C:8]([OH:10])=[O:9])=[N:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10749618ethyl 1,4-dimethyl-1H-pyrazole-3-carboxylate

Product 1

HCID 53256851,4-Dimethyl-1H-pyrazole-3-carboxylic acidYield 41.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using ethyl 1,4-dimethyl-1H-pyrazole-3-carboxylate (440 mg, 2.62 mmol), 1N aqueous sodium hydroxide solution (3 mL, 3 mmol) and ethanol (3 mL), and by a reaction in the same manner as in Reference Example 20, the title compound (152 mg, 41%) was obtained as pale-yellow crystals.

Workup

  1. customby a reaction in the same manner as in Reference Example 20

Sources & evidence

ORD record
ord-cafc6bbbfdbd4151b684d870196df252
Source dataset
uspto-grants-2012_09
Patent number
US08273741B2

Reaction notes

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