HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1,4-Dimethyl-1H-pyrazole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | ethyl 1,4-dimethyl-1H-pyrazole-3-carboxylate | HCID 10749618 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1,4-Dimethyl-1H-pyrazole-3-carboxylic acid | HCID 5325685 | 41.4% |
Reaction Steps
Using ethyl 1,4-dimethyl-1H-pyrazole-3-carboxylate (440 mg, 2.62 mmol), 1N aqueous sodium hydroxide solution (3 mL, 3 mmol) and ethanol (3 mL), and by a reaction in the same manner as in Reference Example 20, the title compound (152 mg, 41%) was obtained as pale-yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273741B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-cafc6bbbfdbd4151b684d870196df252 |
| Source note | uspto-grants-2012_09 |