HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 239115Generated: October 28, 2026
Hydrochloric Acid → 4-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine hydrochloride
https://huagongshe.com/reaction/239115
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 7-benzyl-4-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine | HCID 86686040 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine hydrochloride | HCID 86686041 | — |
Reaction Steps
Palladium charcoal was added to 17 g 7-benzyl-4-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine in 250 mL ethanol and 54 mL 1 M HCl solution. The reaction was stirred at 80° C. and 5 bar hydrogen. The mixture was filtered and evaporated to give 13.1 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08642774B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-4dc2ba35a35e4bf9afeaba733ac24140 |
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| Source note | uspto-grants-2014_02 |
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