Hydrochloric Acid → 4-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine hydrochloride

HRID 239115Notes

Reaction equation

C([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[N:16][CH:17]=[N:18][C:11]=2[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H].[ClH:27]>C(O)C.[Pd]>[ClH:27].[C:19]1([C:15]2[C:12]3[CH2:13][CH2:14][NH:8][CH2:9][CH2:10][C:11]=3[N:18]=[CH:17][N:16]=2)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

Conditions

Temperature: 80 °C

Procedure

Palladium charcoal was added to 17 g 7-benzyl-4-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine in 250 mL ethanol and 54 mL 1 M HCl solution. The reaction was stirred at 80° C. and 5 bar hydrogen. The mixture was filtered and evaporated to give 13.1 g of the desired product.

Workup

filtrationThe mixture was filtered
customevaporated

Sources & evidence

ORD record: ord-4dc2ba35a35e4bf9afeaba733ac24140
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08642774B2

Reaction notes

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