反应详情

温度

150 °C

3.6 g 1-fluor-2-nitrobenzene and 82.7 g potassiumcarbonate were added to 5.3 g 1-benzyl-4-methyl-piperidin-4-ylamine in 50 mL DMSO and the mixture was stirred at 150° C. 24 h. The reaction was diluted with water and the aqueous layer was extracted with ethylacetate. The organic layer was evaporated and the residue purified by column chromatographie on silica gel (heptane/ethylacetate:9/1) to give 5.9 g of the desired product.

1. custom24 h
2. extractionthe aqueous layer was extracted with ethylacetate
3. customThe organic layer was evaporated
4. customthe residue purified by column chromatographie on silica gel (heptane/ethylacetate:9/1)