反应详情

To a solution of ethyl 2-(1-cyano-1-methylethyl)-1,3-thiazole-4-carboxylate (0.9 g, 4.0 mmol) in tetrahydrofuran/methanol/water (=12 mL/4.0 mL/4.0 mL) was added lithium hydroxide monohydrate (330 mg, 8.0 mmol), and the reaction mixture was stirred at room temperature for 10 hr. The mixture was concentrated under reduced pressure, and the obtained aqueous solution was adjusted to pH 5 by adding 1N hydrochloric acid. The mixture was extracted with ethyl acetate, and the organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and filtrated. The solvent was evaporated under reduced pressure to give the title compound (256 mg, 53%) as a white powder.

1. concentrationThe mixture was concentrated under reduced pressure
2. additionby adding 1N hydrochloric acid
3. extractionThe mixture was extracted with ethyl acetate
4. washthe organic layer was washed with saturated brine
5. dry with materialdried over anhydrous sodium sulfate
6. filtrationfiltrated
7. customThe solvent was evaporated under reduced pressure