反应详情

温度

70 °C

168 mg ferrum was added to 160 mL ammonium chloride in 5 mL water. A solution of 244 mg (1-benzyl-4-methyl-piperidin-4-yl)-(2-nitro-phenyl)-amine in 5 mL methanol and 5 mL tetrahydrofuran were added and the mixture was stirred at 70° C. under nitrogen. The mixture was filtered over Celite and water was added to the filtrate. The solution was extracted with ethylacetate. The organic layer was evaporated to yield 121 mg of the desired product.

1. filtrationThe mixture was filtered over Celite and water
2. additionwas added to the filtrate
3. extractionThe solution was extracted with ethylacetate
4. customThe organic layer was evaporated