Sodium Hydroxide → 3-(2-methoxyethoxy)-1-methyl-1H-pyrazole-5-carboxylic acid

HRID 2391173Notes

Reaction equation

HRID 2391173 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:10]=[C:9]([C:11]([O:13]C)=[O:12])[N:8]([CH3:15])[N:7]=1.[OH-].[Na+]>CO>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:10]=[C:9]([C:11]([OH:13])=[O:12])[N:8]([CH3:15])[N:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57441051methyl 3-(2-methoxyethoxy)-1-methyl-1H-pyrazole-5-carboxylate

Product 1

HCID 574410523-(2-methoxyethoxy)-1-methyl-1H-pyrazole-5-carboxylic acidYield 96.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using methyl 3-(2-methoxyethoxy)-1-methyl-1H-pyrazole-5-carboxylate (3.03 g, 14.1 mmol), methanol (15 mL) and 8N aqueous sodium hydroxide solution (3.00 mL), and in the same manner as in Reference Example 58, the title compound (2.72 g, yield 96%) was obtained.

Sources & evidence

ORD record
ord-501d504e23c642d88c559ad4e0314105
Source dataset
uspto-grants-2012_09
Patent number
US08273741B2

Reaction notes

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