反应详情

170 mg methyliodide was added to 320 mg 1-(1-benzyl-4-methyl-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one and 50 mg sodium hydride (60% oil dispersion). The reaction was stirred 1 h at RT. The reaction was diluted with water and extracted with ethylacetate. The organic layer was evaporated and the residue was purified by column chromatographie on silica gel (heptane/ethylacetate/triethylamine:1/1/0.01) to give 155 mg of the desired product.

1. extractionextracted with ethylacetate
2. customThe organic layer was evaporated
3. customthe residue was purified by column chromatographie on silica gel (heptane/ethylacetate/triethylamine:1/1/0.01)