HRID2391191

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6386

tert-Butyl alcohol

C4H10O

HCID8471

Triethylamine

C6H15N

HCID199401

Phosphinic azide, diphenyl-

C12H10N3OP

结构：CC(C)(C#N)c1cccc(C(=O)Nc2cccc(Oc3ccc4nc(C(=O)O)cn4n3)c2)c1

HCID57505456

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)Nc1cn2nc(Oc3cccc(NC(=O)c4cccc(C(C)(C)C#N)c4)c3)ccc2n1

HCID57505457

未命名化合物

收率 71%

PROCEDURE

实验过程

Using 6-(3-{[3-(1-cyano-1-methylethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazine-2-carboxylic acid (826 mg, 1.87 mmol), diphenylphosphoryl azide (771 mg, 2.81 mmol), triethylamine (381 mg, 3.74 mmol) and tert-butanol (30.0 mL), and in the same manner as in Example 64, the title compound (682 mg, 71%) was obtained as a white powder.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2eface3d95a04b8f9d25f2c6b78bff5b
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273741B2
来源说明: uspto-grants-2012_09

反应 SMILES

[C:1]([C:3]([C:6]1[CH:7]=[C:8]([CH:31]=[CH:32][CH:33]=1)[C:9]([NH:11][C:12]1[CH:13]=[C:14]([CH:28]=[CH:29][CH:30]=1)[O:15][C:16]1[CH:17]=[CH:18][C:19]2[N:20]([CH:22]=[C:23](C(O)=O)[N:24]=2)[N:21]=1)=[O:10])([CH3:5])[CH3:4])#[N:2].C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:41])C=CC=CC=1.C([N:53]([CH2:56]C)CC)C.[C:58]([OH:62])([CH3:61])([CH3:60])[CH3:59]>>[C:1]([C:3]([C:6]1[CH:7]=[C:8]([CH:31]=[CH:32][CH:33]=1)[C:9]([NH:11][C:12]1[CH:13]=[C:14]([CH:28]=[CH:29][CH:30]=1)[O:15][C:16]1[CH:17]=[CH:18][C:19]2[N:20]([CH:22]=[C:23]([NH:53][C:56](=[O:41])[O:62][C:58]([CH3:61])([CH3:60])[CH3:59])[N:24]=2)[N:21]=1)=[O:10])([CH3:5])[CH3:4])#[N:2]