HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 239120Generated: October 30, 2026
1-(1-Benzyl-4-methyl-piperidin-4-yl)-3-methyl-1,3-dihydro-benzoimidazol-2-one → 1-Methyl-3-(4-methyl-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one
https://huagongshe.com/reaction/239120
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-(1-Benzyl-4-methyl-piperidin-4-yl)-3-methyl-1,3-dihydro-benzoimidazol-2-one | HCID 86686493 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Methyl-3-(4-methyl-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one | HCID 86686494 | 89.2% |
Reaction Steps
2.5 g palladium charcoal was added to 4.6 g 1-(1-benzyl-4-methyl-piperidin-4-yl)-3-methyl-1,3-dihydro-benzoimidazol-2-one in 100 mL methanol. The reaction was stirred 3 h at 50° C. and 30 bar under hydrogen. The reaction was filtered and evaporated to yields 3 g of the desired product. (M+H)+: 246
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08642774B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-8d97c3252be34a15b6e3a0406495b7a0 |
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| Source note | uspto-grants-2014_02 |
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