Urea → 5,6,7,8-Tetrahydro-4H-oxazolo[4,5-d]azepin-2-ylamine

Participants

Reaction Conditions

Reaction Steps

6.6 g urea was added to 6 g 5-bromo-azepan-4-one hydrobromide. The mixture was stirred 24 h at 70° C. The reaction was basified with 4 N NaOH and extracted with chloroform and ethylacetate. The combined organic layers were evaporated to yield 800 mg of the desired product.

Provenance & Evidence