反应详情

温度

70 °C

6.6 g urea was added to 6 g 5-bromo-azepan-4-one hydrobromide. The mixture was stirred 24 h at 70° C. The reaction was basified with 4 N NaOH and extracted with chloroform and ethylacetate. The combined organic layers were evaporated to yield 800 mg of the desired product.

1. extractionextracted with chloroform and ethylacetate
2. customThe combined organic layers were evaporated