反应详情

3.95 g sodium borohydride was added to 18.9 g benzyl-(2,2-dimethoxy-1-methyl-ethylidene)-amine in 100 mL methanol at 0-5° C. The reaction was stirred over night at RT. The solvent was removed, dissolved in toluol and washed with water and saturated ammoniumchloride solution. The organic layer was evaporated and the residue was purified by column chromatographie on silica gel (cyclohexane/ethylacetate) to give 10.7 g of the desired product.

1. customThe solvent was removed
2. dissolutiondissolved in toluol
3. washwashed with water and saturated ammoniumchloride solution
4. customThe organic layer was evaporated
5. customthe residue was purified by column chromatographie on silica gel (cyclohexane/ethylacetate)