Benzoyl chloride → HCID 24767984, compound

HRID 2391288Notes

Reaction equation

HRID 2391288 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][CH:23]=1)[O:5][C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH:12]=[C:13]([NH:15][C:16]([CH:18]3[CH2:20][CH2:19]3)=[O:17])[N:14]=2)[N:11]=1.[C:24](Cl)(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>CN1CCCC1=O>[CH:18]1([C:16]([NH:15][C:13]2[N:14]=[C:9]3[CH:8]=[CH:7][C:6]([O:5][C:4]4[CH:3]=[C:2]([NH:1][C:24](=[O:31])[C:25]5[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=5)[CH:23]=[CH:22][CH:21]=4)=[N:11][N:10]3[CH:12]=2)=[O:17])[CH2:20][CH2:19]1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 57386059N-[6-(3-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

Product 1

HCID 24767984HCID 24767984, compoundYield 85.1%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Using N-[6-(3-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide (155 mg, 0.50 mmol), N-methylpyrrolidone (3 mL) and benzoyl chloride (0.070 mL, 0.60 mmol), and in the same manner as in Example 162, the title compound (176 mg, yield 85%) was obtained. melting point 265° C.

Sources & evidence

ORD record
ord-1ea8b24d05bc49fb89bc87f99d7dee95
Source dataset
uspto-grants-2012_09
Patent number
US08273741B2

Reaction notes

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