Bromine → HCID 86686500, compound

HRID 239143Notes

Reaction equation

HRID 239143 reaction equation
[BrH:1].[CH3:2][CH:3]1[CH2:9][NH:8][CH2:7][CH2:6][C:5](=[O:10])[CH2:4]1.BrBr>C(O)(=O)C>[BrH:1].[Br:1][CH:4]1[CH:3]([CH3:2])[CH2:9][NH:8][CH2:7][CH2:6][C:5]1=[O:10]

Participants

4

Reactant 2

HCID 24408BromineHCID 86686499HCID 86686499, compound

Product 1

HCID 86686500HCID 86686500, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

6-methylazepan-4-one hydrobromic acid was dissolved in 100 mL acetic acid. A solution of 3.2 mL bromine in 10 mL acetic acid was added. The mixture was stirred for 1.5 h at RT. The volatiles were removed in vacuo and the residue was crystallized with acetonitrile to yield 18.5 g of the desired product. (M+H)+: 228

Workup

  1. customThe volatiles were removed in vacuo
  2. customthe residue was crystallized with acetonitrile

Sources & evidence

ORD record
ord-15ade9be6fd34809b5870feda9887bea
Source dataset
uspto-grants-2014_02
Patent number
US08642774B2

Reaction notes

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