2-Chloro-6-nitrobenzaldehyde → (1-Benzyl-piperidin-4-yl)-(2-chloro-6-nitro-benzyl)-amine

Participants

Reaction Steps

15 g 2-chloro-6-nitro-benzaldehyde and 4-amino-1-benzylpiperidine in 150 mL toluol were refluxed for 3 h. The toluol was removed and the residue was dissolved in 300 mL methanol. 6.6 g sodium borohydride was added and the reaction was refluxed over night. The solvent was removed, water and dichlormethane were added and the layers were separated. The organic layer was washed with water, dried and filtered to yield 29 g of the desired product.

Provenance & Evidence