HCID 18321017, compound → HCID 18321195, compound

HRID 239147Notes

Reaction equation

HRID 239147 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][C:21]=3[Cl:24])[NH:16][C:15]2=[O:25])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>[Ni]>[Cl:24][C:21]1[CH:20]=[CH:19][CH:18]=[C:17]2[C:22]=1[CH2:23][N:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[C:15](=[O:25])[NH:16]2

Participants

4

Reactant 2

HCID 18321017HCID 18321017, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18321195HCID 18321195, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

100 mg (3-(1-benzyl-piperidin-4-yl)-5-chloro-3,4-dihydro-1H-quinazolin-2-one and 15 mg Raney nickel were stirred for 12 h at RT in a hydrogen atmosphere (30 psi). The reaction was filtered and the filtrate was evaporated to give 67 mg of the desired product. (M+H)+: 266

Workup

  1. filtrationThe reaction was filtered
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-159903198b7f4a72b6cac0c7e812f6bf
Source dataset
uspto-grants-2014_02
Patent number
US08642774B2

Reaction notes

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