2-Chloropyrimidine → HCID 71634900, compound

HRID 239148Notes

Reaction equation

Cl[C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[C:8]([O:12][C:13]([N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH:16]1[CH3:21])=[O:14])([CH3:11])([CH3:10])[CH3:9]>>[C:8]([O:12][C:13]([N:15]1[CH2:20][CH2:19][N:18]([C:2]2[N:7]=[CH:6][CH:5]=[CH:4][N:3]=2)[CH2:17][CH:16]1[CH3:21])=[O:14])([CH3:11])([CH3:9])[CH3:10]

Participants

Reactant 2

HCID 744042-Chloropyrimidine

HCID 15087784tert-Butyl 2-methylpiperazine-1-carboxylate

Product 1

HCID 71634900HCID 71634900, compoundYield 98.8%

Conditions

Temperature: 120 °C

Procedure

100 mg 2-chloro-pyrimidine was added to 175 mg 2-Methyl-piperazine-1-carboxylic acid tert-butyl ester and this mixture was stirred for 2 h at 120° C. to give 240 mg of the desired compound. Rt: 1.31 min (method B), (M+H)+: 279

Sources & evidence

ORD record: ord-bad9a4969d944e078a02c282acb79610
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08642774B2

Reaction notes

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