反应详情

5 mL trifluoro acetic acid was added to 240 mg of 2-methyl-4-pyrimidin-2-yl-piperazine-1-carboxylic acid tert-butyl ester in 10 mL dichlormethane. The mixture was stirred for 24 h at RT. The solvent of the mixture was evaporated and the residue was dissolved in dichlormethane and extracted with 10% aqueous potassium hydrogencarbonate. The organic layer was evaporated to yield 150 mg of the desired product. Rt: 0.50 min (method B), (M+H)+: 179

1. customThe solvent of the mixture was evaporated
2. dissolutionthe residue was dissolved in dichlormethane
3. extractionextracted with 10% aqueous potassium hydrogencarbonate
4. customThe organic layer was evaporated