Trifluoroacetic acid → HCID 86686506, compound

HRID 239150Notes

Reaction equation

HRID 239150 reaction equation
FC(F)(F)C(O)=O.C(OC([N:15]1[CH2:20][CH2:19][N:18]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH3:28])[N:22]=2)[C:17](=[O:29])[CH2:16]1)=O)(C)(C)C>ClCCl>[CH3:28][O:27][C:23]1[N:22]=[C:21]([N:18]2[CH2:19][CH2:20][NH:15][CH2:16][C:17]2=[O:29])[CH:26]=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86686507HCID 86686507, compound

Product 1

HCID 86686506HCID 86686506, compoundYield 115.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

35 mL trifluoro acetic acid was added to 5.8 g tert-butyl-4-(6-methoxypyridin-2-yl)-3-oxopiperazine-1-carboxylat in 35 mL dichlormethane under argon. The mixture was stirred for 1 h and evaporated. The residue was purified by chromatographie on silica gel (100% MeOH) to yield 4.5 g of the desired product.

Workup

  1. customevaporated
  2. customThe residue was purified by chromatographie on silica gel (100% MeOH)

Sources & evidence

ORD record
ord-a2491a3dd8744fb4b31ede4679a0e361
Source dataset
uspto-grants-2014_02
Patent number
US08642774B2

Reaction notes

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