Hydrochloric Acid → HCID 57505743, compound

Participants

Reaction Steps

A mixture of 2-oxo-2-{[6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazin-2-yl]amino}ethyl acetate (250 mg, 0.486 mmol), 1N aqueous sodium hydroxide solution (3 mL) and methanol (5 mL) was stirred at room temperature for 3 hr. The reaction mixture was neutralized by the addition of 1N hydrochloric acid, and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and filtrated. The solvent was evaporated under reduced pressure, and the residue was washed with ethanol to give the title compound (185 mg, 81%) as a white powder.

Provenance & Evidence