Hydrochloric Acid → HCID 57505743, compound

HRID 2391514Notes

Reaction equation

HRID 2391514 reaction equation
C([O:4][CH2:5][C:6](=[O:37])[NH:7][C:8]1[N:9]=[C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:24](=[O:35])[C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[CH:26]=4)[CH:18]=3)=[N:12][N:11]2[CH:36]=1)(=O)C.[OH-].[Na+].Cl>CO>[C:6]([NH:7][C:8]1[N:9]=[C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]3[CH:18]=[C:19]([NH:23][C:24](=[O:35])[C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:32])([F:33])[F:34])[CH:26]=4)[CH:20]=[CH:21][CH:22]=3)=[N:12][N:11]2[CH:36]=1)(=[O:37])[CH2:5][OH:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57505742HCID 57505742, compound

Product 1

HCID 57505743HCID 57505743, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-oxo-2-{[6-(3-{[3-(trifluoromethyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazin-2-yl]amino}ethyl acetate (250 mg, 0.486 mmol), 1N aqueous sodium hydroxide solution (3 mL) and methanol (5 mL) was stirred at room temperature for 3 hr. The reaction mixture was neutralized by the addition of 1N hydrochloric acid, and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and filtrated. The solvent was evaporated under reduced pressure, and the residue was washed with ethanol to give the title compound (185 mg, 81%) as a white powder.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltrated
  5. customThe solvent was evaporated under reduced pressure
  6. washthe residue was washed with ethanol

Sources & evidence

ORD record
ord-55e3a4b7a40a4f9d9294006f533fcfc6
Source dataset
uspto-grants-2012_09
Patent number
US08273741B2

Reaction notes

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