Water → 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

HRID 239152Notes

Reaction equation

HRID 239152 reaction equation
[N:1]1[C:6]2[CH2:7][CH2:8][S:9][C:5]=2C(O)=[N:3][C:2]=1O.O=P(Cl)(Cl)[Cl:14].O.Cl[CH2:19][Cl:20]>>[Cl:14][C:2]1[N:3]=[C:19]([Cl:20])[C:5]2[S:9][CH2:8][CH2:7][C:6]=2[N:1]=1

Participants

5

Reactant 4

HCID 962WaterHCID 6344DichloromethaneHCID 24813Phosphorus oxychlorideHCID 178518398HCID 178518398, compound

Product 1

HCID 457899672,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

Procedure

500 mg 6,7-Dihydro-thieno[3,2-d]pyrimidine-2,4-diol and 10 mL phosphoroxychloride was stirred 30 min at 140° C. under microwave conditions. The reaction was added to water and then dichlormethane was added. The mixture was stirred for 20 min. The layers were separated and the dichlormethane layer was evaporated to give 586 mg of the desired product.

Workup

  1. customThe layers were separated
  2. customthe dichlormethane layer was evaporated

Sources & evidence

ORD record
ord-fb3a7f850e1d4539a1d08dda06e9c15d
Source dataset
uspto-grants-2014_02
Patent number
US08642774B2

Reaction notes

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