Hydrochloric Acid → HCID 86686510, compound

HRID 239155Notes

Reaction equation

HRID 239155 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:15]3[S:22][CH2:21][CH2:20][C:16]=3[N:17]=[CH:18][N:19]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[N:11]1([C:14]2[C:15]3[S:22][CH2:21][CH2:20][C:16]=3[N:17]=[CH:18][N:19]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86686509HCID 86686509, compound

Product 1

HCID 86686510HCID 86686510, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

69 mg 4-(6,7-Dihydro-thieno[3,2-d]pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester was stirred in 2 mL 4 mol/L HCl solution in dioxane for 5 h. The mixture was evaporated. The residue was crystallized from isopropanol and diethylether to yield 48 mg of the desired product. (M+H)+: 223

Workup

  1. customThe mixture was evaporated
  2. customThe residue was crystallized from isopropanol and diethylether

Sources & evidence

ORD record
ord-5937451d6ac24ff394525f8bc37e153b
Source dataset
uspto-grants-2014_02
Patent number
US08642774B2

Reaction notes

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