Bromine → HCID 86686061, compound

HRID 239156Notes

Reaction equation

HRID 239156 reaction equation
[Br:1]Br.[BrH:3].[CH3:4][CH:5]1[NH:11][CH2:10][CH2:9][C:8](=[O:12])[CH2:7][CH2:6]1>C(O)(=O)C>[BrH:1].[Br:3][CH:7]1[CH2:6][CH:5]([CH3:4])[NH:11][CH2:10][CH2:9][C:8]1=[O:12].[BrH:1].[Br:1][CH:9]1[C:8](=[O:12])[CH2:7][CH2:6][CH:5]([CH3:4])[NH:11][CH2:10]1

Participants

4

Reactant 2

HCID 24408BromineHCID 86686064HCID 86686064, compound

Product 1

HCID 86686061HCID 86686061, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

9.8 mL bromine was added to 30 g 7-methyl-azepan-4-one hydrobromide in 180 mL acetic acid. The reaction was stirred over night at RT. The reaction was evaporated to yield 33 g of the desired product as isomere mixture. Rf: 0.4 (DCM/MeOH=20/1), (M+H)+=206

Workup

  1. customThe reaction was evaporated

Sources & evidence

ORD record
ord-7fb9c0926f9a4b4a9d7760eb71a17001
Source dataset
uspto-grants-2014_02
Patent number
US08642774B2

Reaction notes

Loading…