Ammonia → HCID 25152659, compound

HRID 2391571Notes

Reaction equation

HRID 2391571 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH:5][C:6]([C:8]1[N:13]=[CH:12][C:11]2[N:14]=[CH:15][N:16]([C:17]3[S:21][C:20]([C:22]([O:24]C)=O)=[C:19]([O:26][CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[C:34]([F:37])([F:36])[F:35])[CH:18]=3)[C:10]=2[CH:9]=1)=[O:7].[NH3:38]>CO>[C:22]([C:20]1[S:21][C:17]([N:16]2[C:10]3[CH:9]=[C:8]([C:6]([NH:5][CH2:4][CH2:3][O:2][CH3:1])=[O:7])[N:13]=[CH:12][C:11]=3[N:14]=[CH:15]2)=[CH:18][C:19]=1[O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[C:34]([F:36])([F:37])[F:35])(=[O:24])[NH2:38]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 68766494HCID 68766494, compound2×

Product 1

HCID 25152659HCID 25152659, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described for example 1, 246 mg of methyl 5-{6-[(2-methoxyethyl)carbamoyl]-1H-imidazo[4,5-c]pyridin-1-yl}-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxylate (compound B8) and 40 ml of a saturated solution of ammonia in methanol give the title compound.

Sources & evidence

ORD record
ord-3eb920ea51dd45f0a68bafbd80feb3d3
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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