Ammonia → HCID 25153285, compound

HRID 2391588Notes

Reaction equation

HRID 2391588 reaction equation
[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[S:14][C:13]([C:15]([O:17]C)=O)=[C:12]([O:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]([F:30])([F:29])[F:28])[CH:11]=2)[CH:2]=1.[NH3:31]>CO>[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[S:14][C:13]([C:15]([NH2:31])=[O:17])=[C:12]([O:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]([F:29])([F:28])[F:30])[CH:11]=2)[CH:2]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 68769258HCID 68769258, compound

Product 1

HCID 25153285HCID 25153285, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described for example 20, 4.41 g of methyl 5-(3H-imidazo[4,5-b]pyridin-3-yl)-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxylate (compound B5b) and 400 ml of a saturated solution of ammonia in methanol yield the title compound.

Sources & evidence

ORD record
ord-cd5c66f7ff6346049432a6580ac2b545
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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