Ammonia → HCID 25153492, compound

HRID 2391591Notes

Reaction equation

HRID 2391591 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]2[N:9]=[CH:10][N:11]([C:12]3[S:16][C:15]([C:17]([O:19]C)=O)=[C:14]([O:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[C:29]([F:32])([F:31])[F:30])[CH:13]=3)[C:6]2=[CH:5][CH:4]=1.[NH3:33]>CO>[CH3:1][O:2][C:3]1[N:8]=[C:7]2[N:9]=[CH:10][N:11]([C:12]3[S:16][C:15]([C:17]([NH2:33])=[O:19])=[C:14]([O:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[C:29]([F:32])([F:31])[F:30])[CH:13]=3)[C:6]2=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 68768566HCID 68768566, compound

Product 1

HCID 25153492HCID 25153492, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described for example 22, 1.5 g of methyl 5-(5-methoxy-1H-imidazo[4,5-b]pyridin-1-yl)-3-{[2-(trifluoromethyl)benzyl]oxy}thio-phene-2-carboxylate (compound B7a) and 200 ml of a saturated solution of ammonia in methanol yield the title compound.

Sources & evidence

ORD record
ord-377f89b8ac4c45d68b11f0cce9ada57a
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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