Ammonia → HCID 68766656, compound

HRID 2391602Notes

Reaction equation

HRID 2391602 reaction equation
[N:1]1([C:10]2[S:14][C:13]([C:15]([O:17]C)=O)=[C:12]([O:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:30])([F:29])[F:28])[CH:22]=3)[CH:11]=2)[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N:3]=[CH:2]1.[NH3:31]>CO>[N:1]1([C:10]2[S:14][C:13]([C:15]([NH2:31])=[O:17])=[C:12]([O:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:28])([F:29])[F:30])[CH:22]=3)[CH:11]=2)[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 68765400HCID 68765400, compound

Product 1

HCID 68766656HCID 68766656, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described for example 33, 27.5 mg of methyl 5-(1H-imidazo[4,5-c]pyridin-1-yl)-3-{[3-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxylate and 5 ml of a saturated solution of ammonia in methanol yield the title compound.

Sources & evidence

ORD record
ord-cecc433cdbad4a94929d2af3f2616476
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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