HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391606Generated: October 29, 2026
Ammonia → 3-[(2-fluorobenzyl)oxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxamide
https://huagongshe.com/reaction/2391606
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | methyl 3-[(2-fluorobenzyl)oxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate | HCID 68765200 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-[(2-fluorobenzyl)oxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxamide | HCID 68768169 | — |
Reaction Steps
A mixture of 50 mg of methyl 3-[(2-fluorobenzyl)oxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate and 15 ml of a saturated solution of ammonia in methanol is stirred in a microwave vial at 125° C. for 4 h in the microwave cavity. The reaction mixture is concentrated to dryness, the resulting residue is recrystallized from 5 ml ethanol to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08273890B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-64b4451fa0cb4688866044cc756106e6 |
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| Source note | uspto-grants-2012_09 |
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