Ammonia → HCID 68767991, compound

HRID 2391607Notes

Reaction equation

HRID 2391607 reaction equation
[F:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][O:7][C:8]2[CH:12]=[C:11]([N:13]3[C:17]4[CH:18]=[N:19][CH:20]=[CH:21][C:16]=4[N:15]=[CH:14]3)[S:10][C:9]=2[C:22]([O:24]C)=O)=[C:4]([C:28]([F:31])([F:30])[F:29])[CH:3]=1.[NH3:32]>CO>[F:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][O:7][C:8]2[CH:12]=[C:11]([N:13]3[C:17]4[CH:18]=[N:19][CH:20]=[CH:21][C:16]=4[N:15]=[CH:14]3)[S:10][C:9]=2[C:22]([NH2:32])=[O:24])=[C:4]([C:28]([F:31])([F:30])[F:29])[CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 68766282HCID 68766282, compound

Product 1

HCID 68767991HCID 68767991, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described for example 38, 92.1 mg of methyl 3-{[4-fluoro-2-(trifluoromethyl)benzyl]oxy}-5-(3H-imidazo[4,5-c]pyridin-3-yl)thiophene-2-carboxylate and 15 ml of a saturated solution of ammonia in methanol yield the title compound.

Sources & evidence

ORD record
ord-817d1d8ac09345c18d75ad6fd66910df
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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