反应详情

In a similar manner as described for example 49 (step 1), 357 mg of 3-[(1R)-1-(2-bromophenyl)ethoxy]-5-[6-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl]thiophene-2-carboxamide, 173 mg of methanesulfonyl chloride, and 153 mg of triethylamine in 7.5 ml dichloromethane give (1-{4-[(1R)-1-(2-bromophenyl)ethoxy]-5-carbamoyl-2-thienyl}-1H-imidazo[4,5-c]pyridin-6-yl)methyl methanesulfonate as crude material that is used for step 2 without further purification.