反应详情

In a similar manner as described for example 49 (step 1), 1.06 g of 3-[(1-(2-fluorophenyl)ethoxy]-5-[6-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl]thiophene-2-carboxamide, 586 mg of methanesulfonyl chloride, and 518 mg of triethylamine in 19 ml dichloromethane give (1-{5-carbamoyl-4-[1-(2-fluorophenyl)ethoxy]-2-thienyl}-1H-imidazo[4,5-c]pyridin-6-yl)methyl methanesulfonate as crude material that is used for step 2 without further purification.