Cyclopropylamine → HCID 68768682, compound

HRID 2391638Notes

Reaction equation

HRID 2391638 reaction equation
CS(O[CH2:6][C:7]1[N:12]=[CH:11][C:10]2[N:13]([C:16]3[S:17][C:18]([C:34](=[O:36])[NH2:35])=[C:19]([O:21][C@@H:22]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[C:30]([F:33])([F:32])[F:31])[CH3:23])[CH:20]=3)[CH:14]=[N:15][C:9]=2[CH:8]=1)(=O)=O.[CH:37]1([NH2:40])[CH2:39][CH2:38]1>ClCCl>[CH:37]1([NH:40][CH2:6][C:7]2[N:12]=[CH:11][C:10]3[N:13]([C:16]4[S:17][C:18]([C:34]([NH2:35])=[O:36])=[C:19]([O:21][C@@H:22]([C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=5[C:30]([F:33])([F:31])[F:32])[CH3:23])[CH:20]=4)[CH:14]=[N:15][C:9]=3[CH:8]=2)[CH2:39][CH2:38]1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 86647106[3-(5-carbamoyl-4-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}-2-thienyl)-3H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate

Product 1

HCID 68768682HCID 68768682, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a similar manner as described for example 58, 289 mg of crude [3-(5-carbamoyl-4-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}-2-thienyl)-3H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate (example 49, step 1) and 0.35 ml cyclopropylamine in 7 ml dichloromethane yield the title compound.

Sources & evidence

ORD record
ord-e5b97dc1b4b241b2ae7111b736299ad8
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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