1-(Morpholinocarbonylmethyl)piperazine → HCID 68766306, compound

HRID 2391647Notes

Reaction equation

HRID 2391647 reaction equation
CS(O[CH2:6][C:7]1[N:12]=[CH:11][C:10]2[N:13]=[CH:14][N:15]([C:16]3[S:17][C:18]([C:34](=[O:36])[NH2:35])=[C:19]([O:21][C@@H:22]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[C:30]([F:33])([F:32])[F:31])[CH3:23])[CH:20]=3)[C:9]=2[CH:8]=1)(=O)=O.[N:37]1([CH2:43][C:44]([N:46]2[CH2:51][CH2:50][O:49][CH2:48][CH2:47]2)=[O:45])[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1>ClCCl>[N:46]1([C:44](=[O:45])[CH2:43][N:37]2[CH2:38][CH2:39][N:40]([CH2:6][C:7]3[N:12]=[CH:11][C:10]4[N:13]=[CH:14][N:15]([C:16]5[S:17][C:18]([C:34]([NH2:35])=[O:36])=[C:19]([O:21][C@@H:22]([C:24]6[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=6[C:30]([F:33])([F:31])[F:32])[CH3:23])[CH:20]=5)[C:9]=4[CH:8]=3)[CH2:41][CH2:42]2)[CH2:47][CH2:48][O:49][CH2:50][CH2:51]1

Participants

4

Reactant 2

HCID 1006221-(Morpholinocarbonylmethyl)piperazineHCID 86647102[1-(5-carbamoyl-4-{(1R)-1-[2-(trifluoro-methyl)phenyl]ethoxy}-2-thienyl)-1H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate

Product 1

HCID 68766306HCID 68766306, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a similar manner as described for example 58, 108 mg of [1-(5-carbamoyl-4-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}-2-thienyl)-1H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate and 213.3 mg of 4-(piperazin-1-ylacetyl)morpholine in 2.5 ml dichloromethane give the title compound.

Sources & evidence

ORD record
ord-4a8c534d270246d7b15428456c5f81cd
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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