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HRID2391648

反应详情

EQUATION

反应方程式

HRID 2391648 的结构方程式

REACTANTS

反应物

2
结构：CCCC[N+](CCCC)(CCCC)CCCC.[F-]
HCID2724141

Tetra-n-butylammonium fluoride

C16H36FN

结构：CC(Oc1cc(-n2cnc3cc(CO[Si](C)(C)C(C)(C)C)ncc32)sc1C(N)=O)c1ccccc1Cl
HCID68770523

未命名化合物

PRODUCTS

生成物

1
结构：CC(Oc1cc(-n2cnc3cc(CO)ncc32)sc1C(N)=O)c1ccccc1Cl
HCID68765333

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

A mixture of 8.19 g of 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3H-imidazo[4,5-c]pyridin-3-yl]-3-[-1-(2-chlorophenyl)ethoxy]thiophene-2-carboxamide in 550 ml THF is cooled to 0° C. At 0° C. 4.14 ml tetra-n-butylammonium fluoride (˜75% in H20) are added. The reaction mixture is allowed to warm to room temperature and stirred for one hour.

WORKUP

后处理

  1. customAt 0° C
  2. temperatureto warm to room temperature