Triethylamine → HCID 86647118, compound

HRID 2391656Notes

Reaction equation

HRID 2391656 reaction equation
[OH:1][CH2:2][C:3]1[N:8]=[CH:7][C:6]2[N:9]=[CH:10][N:11]([C:12]3[S:16][C:15]([C:17]([NH2:19])=[O:18])=[C:14]([O:20][CH:21]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[CH3:22])[CH:13]=3)[C:5]=2[CH:4]=1.[CH3:30][S:31](Cl)(=[O:33])=[O:32].C(N(CC)CC)C>ClCCl>[CH3:30][S:31]([O:1][CH2:2][C:3]1[N:8]=[CH:7][C:6]2[N:9]=[CH:10][N:11]([C:12]3[S:16][C:15]([C:17](=[O:18])[NH2:19])=[C:14]([O:20][CH:21]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[CH3:22])[CH:13]=3)[C:5]=2[CH:4]=1)(=[O:33])=[O:32]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 687670305-[6-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-[1-(2-methylphenyl)ethoxy]thiophene-2-carboxamide

Product 1

HCID 86647118HCID 86647118, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a similar manner as described for example 49 (step 1), 410 mg of 5-[6-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-[1-(2-methylphenyl)ethoxy]thiophene-2-carboxamide, 0.15 ml of methanesulfonyl chloride, and 0.28 ml triethylamine in 15 ml dichloromethane give (1-{5-carbamoyl-4-[1-(2-methylphenyl)ethoxy]-2-thienyl}-1H-imidazo[4,5-c]pyridin-6-yl)methyl methanesulfonate as crude material that is used for step 2 without further purification.

Sources & evidence

ORD record
ord-5bfe81c29dd94866b606b8b862b52620
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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